376 papers
This study reveals that ribosomal RNA expansion segments mediate the formation of conserved ribosome dimers (hibernating disomes) in response to diverse cellular stresses, including puromycin treatment, ER stress, and amino acid depletion, thereby protecting idle ribosomes and regulating protein synthesis.
This study demonstrates that the structured RNA-binding domains and condensation capacity of the ALS-linked protein FUS function as distinct yet synergistic mechanisms to shape its RNA-binding landscape, thereby governing nuclear condensate assembly, DNA damage response, and transcriptional regulation.
This study introduces novel mouse models of Hereditary Hemorrhagic Telangiectasia that recapitulate the somatic second-hit mutations found in patients, demonstrating that these models exhibit more severe and persistent vascular malformations than traditional knockout models, thereby providing a superior platform for investigating long-term disease progression and therapeutic interventions.
This study demonstrates that Group 1 tandem duplication formation and FANCM synthetic lethality are specific consequences of defective BRCA1-mediated DNA end resection, distinguishing the tumorigenic mechanisms of Brca1 exon 11 mutations from those of coiled-coil domain mutants that retain resection competence.
This study demonstrates that human islet amyloid polypeptide (hIAPP) aggregation in type-2 diabetes induces vascular destabilization by downregulating endothelial cell adhesion genes, leading to pericyte detachment and impaired capillary vasomotor function.
This study reveals that SMCHD1 acts as a critical architectural constraint in human myoblasts by maintaining enhancer organization and suppressing hyperactive enhancer networks, as its loss triggers widespread chromatin accessibility changes and rewires MYOD1 into aberrant "enhancer nexuses" that drive transcriptional dysregulation relevant to facioscapulohumeral muscular dystrophy type 2.
This study identifies NISM, a disordered microprotein encoded within the HDAC5 5'-UTR, as a critical regulator of nucleolar integrity and ribosomal RNA synthesis that functions by enhancing the liquid-liquid phase separation of the RNA helicase DHX9.
This study demonstrates that bromide-mediated sulfilimine bonds, catalyzed by the evolutionarily conserved enzyme peroxidasin, covalently interlock the quaternary structure of Collagen IV NC1-hexamers across diverse metazoans, a critical mechanism that stabilized basement membrane scaffolds and enabled the evolution of multicellularity.
This study reveals that the inhibitory effect of the conserved Leu-Pro CUC-CCG codon pair in *Saccharomyces cerevisiae* is mediated by wobble decoding via tRNALeu(UAG) and ribosome collisions, with its impact modulated by ribosome concentration and the TOR pathway to potentially regulate gene expression during starvation.
This study reveals that a conserved, negatively charged intrinsically disordered region in mammalian Dicer acts as an autoinhibitory element that stabilizes a pre-dicing state to ensure the high-fidelity processing of microRNA precursors while suppressing broader RNAi activity.
This study demonstrates that long-read sequencing of the 18S rRNA gene provides superior taxonomic resolution and a more robust representation of freshwater biofilm communities compared to short-read methods, highlighting the critical impact of sequencing strategy on eDNA-based biomonitoring accuracy.
This study reveals that the active histone mark H2BK120ub directly enhances PRC1 enzymatic activity and modulates its subunit composition to facilitate the targeted deposition of the repressive H2AK119ub mark on specific developmental genes, thereby establishing a synergistic crosstalk mechanism between Trithorax and Polycomb complexes.
This study reveals that the conserved long non-coding RNA ACHLYS regulates alternative splicing during Arabidopsis root development by directly interacting with the splicing factor NSRa to modulate its biomolecular condensates and phase separation, thereby fine-tuning the transcriptome output essential for organogenesis.
This study identifies HELZ as a unique RNA-DNA helicase that resolves R loops by unwinding RNA-DNA hybrids with 5' ssRNA overhangs, thereby facilitating BRCA1 recruitment and homologous recombination repair to maintain genome stability and confer resistance to DNA-damaging agents.
This study reveals that DNA methylation subtly alters H2A.Z nucleosome stability and suppresses SRCAP-mediated deposition to drive the preferential association of H2A.Z with unmethylated DNA, while a secondary, methylation-insensitive mechanism also contributes to this mutually exclusive genomic distribution.
This study resolves the paradox of cohesin's modest impact on steady-state gene expression by demonstrating that it acts as a transcriptional gatekeeper which simultaneously promotes Pol II recruitment and restrains pause release to ensure transcriptional processivity and robust induction in response to stimuli.
This study presents the first development and validation of 21 nuclear SSR markers for the tropical leafy vegetable aibika (*Abelmoschus manihot*) using Illumina MiSeq shotgun sequencing data, demonstrating their utility in assessing genetic diversity to support genebank management and breeding programs.
This paper introduces "Castling," a novel therapeutic strategy that rewires pathological gene networks by swapping disease-promoting and protective microRNAs using the TRIPLE genome-editing technology, which was successfully demonstrated to delay CAR T cell dysfunction in a chronic antigen stimulation model.
This study reveals that despite independent evolutionary origins, diverse poly-HAMP arrays in prokaryotic signaling systems converge on a conserved signal transduction mechanism driven by the axial rotation of helices, as evidenced by crystal structures of *Myxococcus xanthus* HskS and extensive AlphaFold2 modeling.
This study demonstrates that laminin-2 is essential for maintaining myotendinous junction stability in vivo, as its absence in LAMA2-related muscular dystrophy causes structural disruption and proteomic shifts that are partially driven by altered mechanical loading.